104 women (mean age 59.5±8.7 many years) with RA underwent clinical and laboratory examination, dual-energy X-ray absorptiometry. The degree of PA and nutritional status had been assessed using the International physical working out Questionnaire (IPAQ) and Mini Dietary Assessment (MNA) surveys, respectively. Sarcopenic phenotype ended up being identified in 37.1% of clients. Moderate and reduced PA levels were recognized in 44.2 and 7.8per cent, correspondingly, threat of malnutrition – in 50% of persons. In multivariate logistic regression analysis, factors from the sarcopenic phenotype had been determined the regularity of energetic PA<3 times a week [odds ratio – OR 5.12 (95% confidence period – CI 1.15-22.94); and insufficient calcium intake.52% of women with RA had moderate оr reasonable PA amounts, and 50% of clients had been vulnerable to malnutrition. The possibility of sarcopenic phenotype related to a decreased frequency of strenuous PA, low hiking time, danger of malnutrition, human anatomy mass index less then 25 kg/m2 and inadequate calcium consumption. Among clients with SLE a higher frequency of anxiety-depressive spectrum problems (ADSD) and intellectual disability (CI) was revealed. There clearly was a link of greater seriousness of despair with high SLE task index, acute/subacute start of the disease course based on the category of V.A. Nasonova, relapsing-remitting and chronic energetic present illness activity patterns of SLE according to the classification of S. Barr – M. Petri. Anxiety problems were associated with subacute onset and relapsing-remitting infection activity patterns of SLE and are not involving SLE activity list. Manic depression was recognized more frequently in patients with chronic SLE. Acute psychosis/delirium had been related to severe start of SLE. Natural CI had been related to APS, chronic onset and lengthy quiescent disease activity habits of SLE. The episindrome and schizotypal condition in customers with SLE tend to be more often brought on by concomitant APS. Customers with high SLE activity list should be of particular concern to rheumatologists about the analysis of despression symptoms. Clients with concomitant APS need appropriate diagnosis and remedy for CI and episindrome in order to increase the prognosis of the infection and also the general total well being.Patients with high SLE activity list must certanly be of specific concern to rheumatologists about the diagnosis of depressive disorders. Customers with concomitant APS need appropriate analysis and remedy for CI and episindrome so that you can improve prognosis for the illness additionally the total well being. In Russia, also throughout the world, making use of glucocorticoids (GC) when you look at the treatment of arthritis rheumatoid (RA) is extensive, frequently going beyond the strategies for both period and dose routine, which makes it highly relevant to study the long-term consequences of such a “wrong” (EULAR, 2022) utilization of GC in RA therapy. The analysis included 182 RA clients with reasonable CVR (mSCORE<1%) with no set up cardiovascular diseases and a control team comprising 100 folks. Atherosclerotic lesion of the carotid arteries had been evaluated using Doppler ultrasound associated with the carotid arteries and had been decided by the detection of atherosclerotic plaque (ASP) – the area escalation in the thickness associated with intima-media complex (IMT) >1.5 mm. =0.02). The regularity of ASP in RA patients with reasonable CVR would not depend on the disease’s phase or activity and continuous treatment. In RA, the recognition of subclinical atherosclerosis had been connected with traditional risk factors carotid ASP were recognized 4 times more often in males compared to ladies (48% versus 12%, Subclinical atherosclerotic lesions for the carotid arteries had been observed in 24% of RA clients with reduced Angioimmunoblastic T cell lymphoma aerobic risk and had been recognized very nearly 2 times more frequently compared to the control group. In RA patients with low CVR, the possibility of developing carotid ASP increased by 2-3 times with concomitant hypertension and dyslipidemia. The carotid IMT had been associated with standard danger factors – age, sex, lipid amounts and blood pressure levels indicators, in situations of detection of ASP – with an immunoinflammatory marker – sCD40L.Immune-inflammatory (autoimmune and autoinflammatory) rheumatic conditions are extensive severe chronic inflammatory diseases and also “models” for learning the basic components of pathogenesis and way of pharmacotherapy of other conditions associated with autoimmunity and/or autoinflammation. Uncontrolled inflammation resulting in hypercoagulation kinds the foundation of “thromboinflammation”, which can be considered a universal pathogenetic device insurance medicine of organ participation in immune-inflammatory rheumatic conditions, as well as in COVID-19 and atherosclerotic vascular lesions (atherothrombosis). Thrombo-inflammatory components play a crucial role in systemic lupus erythematosus and antiphospholipid syndrome. Russian rheumatology, underneath the management of academician Valentina Alexandrovna Nasonova, greatly added to the analysis find more of those conditions.